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Filtered Search Results
Medchemexpress LLC Noscapine (hydrochloride) | 912-60-7 | 99.9% | 449.88 | 1 G
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Noscapine (hydrochloride) is an orally active phthalideisoquinoline alkaloid with potent antitussive properties. It activates sigma opioid receptors and acts as a non-competitive Bradykinin inhibitor. This compound also disrupts microtubule dynamics, induces mitotic arrest and apoptosis.
- Orally active phthalideisoquinoline alkaloid
- Potent antitussive properties
- Activates sigma opioid receptors and acts as a non-competitive Bradykinin inhibitor
- Disrupts microtubule dynamics, induces mitotic arrest and apoptosis
- Exhibits anticancer, neuroprotective, and anti-inflammatory activities
- Can cross the blood-brain barrier
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC SB-277011 (hydrochloride) | 215804-67-4 | 99.6% | 475.02 | 25 MG
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SB-277011 hydrochloride is a potent, selective, orally bioavailable, and brain-penetrant dopamine D3 receptor (D3R) antagonist. It demonstrates 80- to 100-fold selectivity over other dopamine receptors.
- Ki values of 10.7 nM and 11.2 nM at rodent and human D3R, respectively.
- Selectivity over D2, 5-HT1B, and 5-HT1D receptors.
- Oral bioavailability of 43% and a half-life of 2.0 h in rats.
- High brain-penetrant (brain:blood ratio of 3.6:1).
- Reverses quinelorane effects in the nucleus accumbens at 3 mg/kg (p.o.) in rats.
- Reduces intravenous cocaine self-administration in rats (12.5-25 mg/kg, i.p.).
- Inhibits basal and cocaine-enhanced locomotion in rats at 50 mg/kg.
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Medchemexpress LLC Nordoxepin hydrochloride | 2887-91-4 | 99.9% | 301.81 g/mol | C18H20ClNO | 10 MG
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Nordoxepin hydrochloride is the primary metabolite of the tricyclic antidepressant doxepin and is provided as a solid research reagent for analytical, pharmacological, and metabolic studies. It is supplied with characterized purity and storage recommendations and is intended for research use only (not for human or veterinary use).
- Chemical identity: CAS 2887-91-4; formula C18H20ClNO; MW 301.81 g/mol.
- High purity (99.94%).
- Appearance: solid; store sealed and away from moisture.
- Storage in solvent: -80°C up to 6 months; -20°C up to 1 month.
- Intended applications: analytical and pharmacokinetic research.
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Medchemexpress LLC Nimustine hydrochloride (ACNU) | 55661-38-6 | 98.2% | 309.15 | 1 ML
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Nimustine hydrochloride (ACNU) is the hydrochloride salt form of Nimustine. It functions as an alkylating agent by inducing DNA double-strand breaks (DSBs) and inter-strand crosslinks (ICLs), which activates the DNA damage response (DDR) signaling pathway. It also activates the p38 MAPK/JNK signaling pathway and demonstrates antitumor activity.
- Induces DNA double-strand breaks and inter-strand crosslinks.
- Activates DNA damage response signaling.
- Activates p38 MAPK/JNK signaling.
- Demonstrates antitumor activity.
- Exhibits cytotoxicity against human U87MG cells.
- Induces apoptosis in LN-229 cells.
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Medchemexpress LLC SRI-37330 hydrochloride | 2322245-49-6 | 99.7% | C16H20ClF3N4O2S | 25 MG
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SRI-37330 hydrochloride is an orally bioavailable thioredoxin-interacting protein (TXNIP) inhibitor. It inhibits glucagon secretion and function, reduces hepatic glucose production, and reverses hepatic steatosis. This compound can be used for type 2 diabetes research.
- Inhibits activity of human TXNIP promoter in INS-1 cells.
- Decreases mRNA and protein levels of TXNIP in INS-1 cells.
- Inhibits polymerase II (Pol II) binding to the E-box motif region of the TXNIP promoter.
- Lowers glucagon secretion in TC1-6 cells.
- Inhibits glucagon-induced glucose output from primary hepatocytes.
- Decreases glucagon secretion and action in mice.
- Blocks hepatic glucose output in mice.
- Reverses obesity- and streptozotocin-induced diabetes and hepatic steatosis in mice.
- Well tolerated in male C57BL/6J mice.
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Medchemexpress LLC Claramine hydrochloride | 1430194-56-1 | 99.1% | 625.45 g/mol | C37H73ClN4O | 10 MG
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Claramine hydrochloride is a steroidal polyamine research compound reported to cross the blood-brain barrier and to modulate lipid membrane properties. It is supplied as a powder for laboratory research use only.
- Molecular formula: C37H73ClN4O.
- Molecular weight: 625.45 g/mol.
- Cas number: 1430194-56-1.
- Form: powder, white to off-white solid.
- Purity: 99.1% (HPLC, batch certificate of analysis).
- Solubility: DMSO 2.2 mg/mL (3.52 mM; ultrasonic warming to 60°C recommended).
- Storage: powder -20°C (up to 3 years) or 4°C (up to 2 years); in solvent -80°C (up to 6 months).
- Intended use: for research use only, not for human or clinical applications.
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Medchemexpress LLC Yonkenafil hydrochloride | 804519-64-0 | 99.4% | 524.08 | C24H34ClN5O4S | 100MG
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Yonkenafil hydrochloride is a phosphodiesterase 5 (PDE5) inhibitor provided as the hydrochloride salt for preclinical research. It has been reported to reduce cerebral infarction and neuronal damage and to modulate neurogenesis, with formulation guidance for both in vitro and in vivo use.
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Medchemexpress LLC Acotiamide hydrochloride | 185104-11-4 | 99.6% | 10 MG
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Acotiamide hydrochloride is a research-grade small molecule and reversible acetylcholinesterase (AChE) inhibitor (IC50 1.79 μM) used to study gastric motility, delayed gastric emptying, and functional dyspepsia. Supplied as the hydrochloride salt with high reported purity for biochemical and pharmacological research.
- Selective, reversible AChE inhibitor with reported IC50 1.79 μM.
- Suitable for studies of gastric motility and functional dyspepsia models.
- Reported high purity (99.62%), appropriate for assay use.
- Storage: sealed at 4°C; in solvent store at -80°C (6 months) or -20°C (1 month).
- Provided in small milligram pack sizes for laboratory research.
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Medchemexpress LLC Yonkenafil hydrochloride | 804519-64-0 | 99.4% | 524.08 | C24H34ClN5O4S | 5MG
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Yonkenafil hydrochloride is the hydrochloride salt of a selective phosphodiesterase 5 (PDE5) inhibitor supplied for research use. It is provided as a high-purity solid suitable for in vitro and preclinical studies involving PDE5-related pathways, neuroscience, and pharmacology. Typical solvent compatibility includes DMSO; follow the SDS and laboratory safety procedures.
- High purity suitable for research.
- Solid form for accurate weighing and formulation.
- Soluble in DMSO for assay preparation.
- Appropriate for in vitro and preclinical pharmacology studies.
- Available in small-scale vials for dose-ranging experiments.
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Medchemexpress LLC (S,S,S)-AHPC hydrochloride | 2115897-23-7 | 99.2% | 467.02 | C22H31ClN4O3S | 5MG
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(S,S,S)-AHPC hydrochloride is the hydrochloride salt of an AHPC-derived VHL ligand used as a building block and negative control in E3 ligase recruitment and PROTAC research. It facilitates the study of VHL-mediated ubiquitination and proteasomal degradation, and is supplied for synthetic and assay applications in small research quantities.
- High purity 99.2%
- Molecular weight 467.02
- Chemical formula C22H31ClN4O3S
- Solid white to yellow appearance
- Suitable as a negative control and VHL ligand building block for PROTAC design
- Available in small milligram pack sizes for research use
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Medchemexpress LLC DC-BPi-11 hydrochloride | 00-00-0 | 97.0% | C20H24ClN5O2S | 10MG
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DC-BPi-11 hydrochloride is a research-grade small-molecule inhibitor of the bromodomain PHD finger transcription factor (BPTF) used in epigenetics and cancer research. It has demonstrated inhibition of leukemia cell proliferation and a reported IC50 of 698 nM against BPTF. The compound is supplied as a powder and analytical batch documentation reports a purity of 97.0%.
- Inhibits BPTF with an IC50 of 698 nM.
- Demonstrates inhibition of leukemia cell proliferation.
- Supplied as a powder for handling and storage flexibility.
- Powder stable at -20°C for up to 3 years.
- High reported purity: 97.0%.
- Chemical formula C20H24ClN5O2S; molecular weight 433.95.
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Medchemexpress LLC Gyki 53655 (hydrochloride) | 143692-48-2 | MFCD01941362 | 98.4% | 388.85 g·mol⁻¹ | C19H21ClN4O3 | 1 ML
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GYKI 53655 hydrochloride is a selective, non-competitive antagonist of AMPA receptors used in electrophysiology and receptor pharmacology research. The hydrochloride salt is available as a high-purity solid or as a ready-to-use 10 mM solution in DMSO.
- Selective non-competitive AMPA and kainate receptor antagonist.
- Available as 10 mM solution in DMSO (1 mL) or as solid doses.
- High purity (~98.4%) suitable for in vitro studies.
- Molecular weight 388.85 g·mol⁻¹ and formula C19H21ClN4O3.
- Recommended storage: solid at 4°C; solution at -80°C for long-term storage.
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Medchemexpress LLC Defactinib hydrochloride | 1073160-26-5 | 99.4% | 50 MG
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Defactinib hydrochloride is the hydrochloride salt of defactinib (VS-6063; PF-04554878), a small-molecule focal adhesion kinase (FAK) inhibitor used in research to study FAK signaling, tumor cell motility, and antineoplastic and antiangiogenic mechanisms.
- Inhibits FAK phosphorylation at Tyr397 in a time- and dose-dependent manner.
- Hydrochloride salt form, off-white powder suitable for research use.
- Molecular formula C20H22ClF3N8O3S; molecular weight 546.95 g/mol.
- Reported purity 99.35% with available certificate of analysis.
- Available in multiple pack sizes, including 50 mg.
- Supporting documents available: data sheet, COA, and SDS.
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Medchemexpress LLC Acotiamide hydrochloride | 185104-11-4 | 99.6% | 25 MG
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Acotiamide hydrochloride is the hydrochloride salt of acotiamide, provided as a research-grade solid reagent used to study gastric motility, delayed gastric emptying, and related gastrointestinal disorders. It is supplied in small pack sizes with high reported purity suitable for analytical and in vitro research.
- Orally active, reversible acetylcholinesterase inhibitor (reported IC50 ~1.79 μM).
- Hydrochloride salt for improved stability and solubility.
- High reported purity for research applications (reported ~99.6%).
- Molecular formula C21H31ClN4O5S; molecular weight 487.01.
- Available in small research pack sizes such as 25 mg.
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Medchemexpress LLC Trazodone hydrochloride | 25332-39-2 | 99.6% | 100 MG
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Trazodone hydrochloride is a triazolopyridine derivative that belongs to the class of serotonin receptor antagonists and reuptake inhibitors (SARIs). It has antidepressant and anti-insomnious activity, exerting antagonistic properties against α1- and α2-adrenergic receptors and histamine H1 receptors with minimal anticholinergic effects.
- Triazolopyridine derivative
- Serotonin receptor antagonist and reuptake inhibitor
- Exhibits antidepressant activity
- Possesses anti-insomnious activity
- Antagonizes α1- and α2-adrenergic receptors
- Antagonizes histamine H1 receptors
- Shows minimal anticholinergic effects
- Demonstrates neuroprotective effects
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